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There are many types of Immunodeficiency, and they occur more often than is commonly thought. There are 2 groups of Immune Deficiency such as Inherited and Acquired. Most common clinical manifestations of immunodeficiency are continuous or recurrent health problems such as sinus, ear, throat and lung infections, persistent skin rashes, gastro-intestinal symptoms, etc. An allergy and immunology specialist can help by making a proper diagnosis and crafting an appropriate management program to decrease the impact of immunodeficiency to the individual’s health.